Endocrine Abstracts

Background: Carbohydrate-restricted diets in type 1 diabetes mellitus (T1DM) are highly controversial. A commonly held concern is that a low carbohydrate diet may more readily result in conversion to diabetic ketoacidosis – one of the most severe complications of poorly managed T1DM. Of note, there is no clear evidence for this phenomenon. We evaluated metabolic profiles in patients with T1DM who had self-selected carbohydrate-restricted diets.<p clas...

Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...